Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
| dc.contributor.author | Sackeyfio, A.C. | |
| dc.contributor.author | Amankwaah, D.K. | |
| dc.contributor.author | Yahaya, A.S. | |
| dc.date.accessioned | 2013-06-21T14:15:10Z | |
| dc.date.accessioned | 2017-10-16T11:43:42Z | |
| dc.date.available | 2013-06-21T14:15:10Z | |
| dc.date.available | 2017-10-16T11:43:42Z | |
| dc.date.issued | 1987 | |
| dc.description.abstract | The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics | en_US |
| dc.identifier.citation | Sackeyfio, A. C., Amankwaah, D. K., & Yahaya, A. S. (1987). Interaction between chloroquine and indomethacin in airways smooth muscle in vivo. European Journal of Pharmacology, 137(1), 135-138. | en_US |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/3854 | |
| dc.language.iso | en | en_US |
| dc.publisher | European Journal of Pharmacology | en_US |
| dc.title | Interaction between chloroquine and indomethacin in airways smooth muscle in vivo | en_US |
| dc.type | Article | en_US |