Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates

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dc.contributor.authorChirawurah, J.D.
dc.contributor.authorAnsah, F.
dc.contributor.authorNyarko, P.B.
dc.contributor.authorDuodu, S.
dc.contributor.authorAniweh, Y.
dc.contributor.authorAwandare, G.A.
dc.date.accessioned2019-02-06T10:24:25Z
dc.date.available2019-02-06T10:24:25Z
dc.date.issued2017-12
dc.description.abstractMalaria remains a major cause of childhood deaths in resource-limited settings. In the absence of an effective vaccine, drugs and other interventions have played very significant roles in combating the scourge of malaria. The recent reports of resistance to artemisinin necessitate the need for new antimalarial drugs with novel mechanisms of action. Towards the development of new, affordable and easily accessible antimalarial drugs for endemic regions, the Medicines for Malaria Venture (MMV) assembled a total of 400 active antimalarial compounds called the Malaria Box. The potency and the efficacy of the Malaria Box Compounds have been determined mainly using laboratory strains of P. falciparum. This study investigated the potency of twenty compounds from the Malaria Box against four clinical isolates from Ghana, using optimized in vitro growth inhibitory assays. Seven out of the 20 compounds screened had 50% inhibitory concentration (IC50) below 500 nM. The most active among the selected compounds was MMV006087 (average IC50 of 30.79 nM). Variations in the potency of the Malaria Box Compounds were observed between P. falciparum clinical isolates and Dd2 strain. We also investigated the sensitivity of the clinical isolates to chloroquine and artesunate. The N093 clinical isolate was found to be resistant to chloroquine but showed high sensitivity to artesunate. The results underscore the importance of including clinical isolates with different drug-resistant backgrounds, in addition to laboratory strains, in validating potential compounds during antimalarial compound screening programs. © 2017 The Authorsen_US
dc.identifier.otherdoi: 10.1016/j.ijpddr.2017.10.005
dc.identifier.otherVol. 7(3): pp 399-406
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/27275
dc.language.isoenen_US
dc.publisherInternational Journal for Parasitology: Drugs and Drug Resistanceen_US
dc.subjectClinical isolatesen_US
dc.subjectCompoundsen_US
dc.subjectErythrocytesen_US
dc.subjectMalaria boxen_US
dc.subjectPlasmodiumen_US
dc.subjectPotencyen_US
dc.titleAntimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolatesen_US
dc.typeArticleen_US

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