A Chronic toxicity study of the ground root bark of Capparis erythrocarpus (Cappareceae) in male Sprague-dawley rats

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dc.contributor.authorOkine, L.K.N.
dc.contributor.authorMartey, O.N.K.
dc.contributor.authorArmah, G.E.
dc.contributor.authorSittie, A.A.
dc.date.accessioned2018-12-14T09:59:26Z
dc.date.available2018-12-14T09:59:26Z
dc.date.issued2013-12
dc.description.abstractThe safety evaluation of Capparis erythrocarpus (CE) on chronic administration at 18 and 180 mg kg-1 body weight for 6 months was investigated in male Sprague-Dawley rats. The effects of CE on certain serum biochemical, haematological, urine and histopathological determinations were used as indices of organ specific toxicity. Also the effects of CE on rat blood clotting time and pentobarbital-induced sleeping time were determined. Results indicate that CE had no effect on urine, haematological and serum biochemical indices at termination of treatment with the exception of serum ALT level which was significantly (p<0.05) attenuated in a dose-dependent fashion (21-35%). There were also no differences in blood clotting time and pentobarbital-induced sleeping time between CE-treated and control animals. Histopathological studies showed that CE did not adversely affect the morphology of the liver, kidney and heart tissues. However, lungs of CE-treated animals showed slight but insignificant inflammatory response in alveolar areas and Clara cell hyperplasia without the thickening of alveolar septa and bronchiolar epithelial wall. Organ weights were not adversely affected by CE treatment. There were significant (p<0.05) changes in weight of CE-treated animals with duration of treatment compared to control. These results suggest that there is no organ specific toxicity associated with chronic administration of CE in rats and its ability to reduce body weight may be useful for slimming in obese persons. © 2013 Asian Network for Scientific Information.en_US
dc.identifier.citationO.N.K. Martey, G.E. Armah, A.A. Sittie and L.K.N. Okine, 2013. A Chronic Toxicity Study of the Ground Root Bark of Capparis erythrocarpus (Cappareceae) in Male Sprague-dawley Rats. Pakistan Journal of Biological Sciences, 16: 1706-1713.en_US
dc.identifier.otherDOI: 10.3923/pjbs.2013.1706.1713
dc.identifier.otherVolume 16 (23): pp 1706-1713
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/26417
dc.language.isoenen_US
dc.publisherPakistan Journal of Biological Sciencesen_US
dc.subjectCapparis erythrocarpusen_US
dc.subjectHistopathologyen_US
dc.subjectOrgansen_US
dc.subjectRaten_US
dc.subjectToxicityen_US
dc.titleA Chronic toxicity study of the ground root bark of Capparis erythrocarpus (Cappareceae) in male Sprague-dawley ratsen_US
dc.typeArticleen_US

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