Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum

Abstract

Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-(S)-nerolidol and seven labdanes, coronarin B, galanal A and B, galanolactone, (E)-8β,17-epoxylabd-12-ene-15,16-dial, (+)-(E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact. The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.