Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials

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dc.contributor.authorO' Neill, P.M.
dc.contributor.authorSabbani, S.
dc.contributor.authorNixon, G.L.
dc.contributor.authorSchnaderbeck, M.
dc.contributor.authorRoberts, N.L.
dc.contributor.authorShore, E.R.
dc.contributor.authorRiley, C.
dc.contributor.authorMurphy, B.
dc.contributor.authorMcGillan, P.
dc.contributor.authorWard, S.A.
dc.contributor.authorDavies, J.
dc.contributor.authorAmewu, R.K.
dc.date.accessioned2019-04-16T12:06:57Z
dc.date.available2019-04-16T12:06:57Z
dc.date.issued2016
dc.description.abstractAn efficient route to the synthesis of potent antimalarial aryloxy 1,2,4,5-tetraoxanes is described that permits parallel synthesis for Structure–Activity Relationship (SAR) investigations. Brief details of the in vitro and in vivo antimalarial evaluation are included which enables identification of antimalarial leads for further development. Also described is an improved approach to the synthesis of a selected late-lead compound in just four or five synthetic steps from commercially available starting materials. © 2016en_US
dc.identifier.issn404020
dc.identifier.otherdoi.10.1016/j.tet.2016.08.043
dc.identifier.othervol.72 (40). 6118 - 6126
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29309
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.subjectAntimalarialen_US
dc.subjectChemoselective reductionen_US
dc.subjectMedicinal chemistryen_US
dc.subjectPeroxide chemistryen_US
dc.subjectReductive aminationen_US
dc.titleOptimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarialsen_US
dc.typeArticleen_US

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