Reproductive factors and risk of breast cancer by tumor subtypes among Ghanaian women: A population-based case–control study

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dc.contributor.authorClegg-Lamptey, J-N.
dc.contributor.authorFigueroa, J.D.
dc.contributor.authorLynn, B.C.D.
dc.contributor.authorEdusei, L.
dc.contributor.authorTitiloye, N.
dc.contributor.authorAdjei, E.
dc.contributor.authorYarney, J.
dc.contributor.authorWiafe-Addai, B.
dc.contributor.authorAwuah, B.
dc.contributor.authorDuggan, M.A.
dc.contributor.authorWiafe, S.
dc.contributor.authorNyarko, K.
dc.contributor.authorAitpillah, F.
dc.contributor.authorAnsong, D.
dc.contributor.authorHewitt, S.M.
dc.contributor.authorAhearn, T.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorBrinton, L.A.
dc.contributor.authorGhana Breast Health Study Team
dc.date.accessioned2020-06-29T12:38:22Z
dc.date.available2020-06-29T12:38:22Z
dc.date.issued2020-02-18
dc.descriptionResearch Articleen_US
dc.description.abstractHigher proportions of early-onset and estrogen receptor (ER) negative cancers are observed in women of African ancestry than in women of European ancestry. Differences in risk factor distributions and associations by age at diagnosis and ER status may explain this disparity. We analyzed data from 1,126 cases (aged 18–74 years) with invasive breast cancer and 2,106 controls recruited from a population-based case–control study in Ghana. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for menstrual and reproductive factors using polytomous logistic regression models adjusted for potential confounders. Among controls, medians for age at menarche, parity, age at first birth, and breastfeeding/pregnancy were 15 years, 4 births, 20 years and 18 months, respectively. For women ≥50 years, parity and extended breastfeeding were associated with decreased risks: >5 births vs. nulliparous, OR 0.40 (95% CI 0.20–0.83) and 0.71 (95% CI 0.51–0.98) for ≥19 vs. <13 breastfeeding months/pregnancy, which did not differ by ER. In contrast, for earlier onset cases (<50 years) parity was associated with increased risk for ER-negative tumors (p-heterogeneity by ER = 0.02), which was offset by extended breastfeeding. Similar associations were observed by intrinsic-like subtypes. Less consistent relationships were observed with ages at menarche and first birth. Reproductive risk factor distributions are different from European populations but exhibited etiologic heterogeneity by age at diagnosis and ER status similar to other populations. Differences in reproductive patterns and subtype heterogeneity are consistent with racial disparities in subtype distributions.en_US
dc.identifier.otherhttps://doi.org/10.1002/ijc.32929
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/35387
dc.language.isoenen_US
dc.publisherInternational Journal of Canceren_US
dc.relation.ispartofseries2020;
dc.subjectreproductive risk factorsen_US
dc.subjectsubtype heterogeneityen_US
dc.subjectracial disparitiesen_US
dc.subjectbreast canceren_US
dc.titleReproductive factors and risk of breast cancer by tumor subtypes among Ghanaian women: A population-based case–control studyen_US
dc.typeArticleen_US

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