Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus.

Simple item page
dc.contributor.authorHori, T.
dc.contributor.authorBarnor, J.
dc.contributor.authorNguyen Huu, T.
dc.contributor.authorMorinaga, O.
dc.contributor.authorHamano, A.
dc.contributor.authorNdzinu, J.
dc.contributor.authorFrimpong, A.
dc.contributor.authorMinta-Asare, K.
dc.contributor.authorAmoa-Bosompem, M.
dc.contributor.authorBrandful, J.
dc.contributor.authorOdoom, J.
dc.contributor.authorBonney, J.
dc.contributor.authorTuffour, I.
dc.contributor.authorOwusu, B.-A.
dc.contributor.authorOfosuhene, M.
dc.contributor.authorAtchoglo, P.
dc.contributor.authorSakyiamah, M.
dc.contributor.authorAdegle, R.
dc.contributor.authorAppiah-Opong, R.
dc.contributor.authorAmpofo, W.
dc.contributor.authorKoram, K.
dc.contributor.authorNyarko, A.
dc.contributor.authorOkine, L.
dc.contributor.authorEdoh, D.
dc.contributor.authorAppiah, A.
dc.contributor.authorUto, T.
dc.contributor.authorYoshinaka, Y.
dc.contributor.authorUota, S.
dc.contributor.authorShoyama, Y.
dc.contributor.authorYamaoka, S.
dc.date.accessioned2018-09-17T09:28:29Z
dc.date.available2018-09-17T09:28:29Z
dc.date.issued2015-04
dc.description.abstractDespite remarkable advances in combination antiretroviral therapy (cART), human immunodeficiency virus type 1 (HIV-1) infection remains incurable due to the incomplete elimination of the replication-competent virus, which persists in latent reservoirs. Strategies for targeting HIV reservoirs for eradication that involves reactivation of latent proviruses while protecting uninfected cells by cART are urgently needed for cure of HIV infection. We screened medicinal plant extracts for compounds that could reactivate the latent HIV-1 provirus and identified a procyanidin trimer C1 derived from Theobroma cacao as a potent activator of the provirus in human T cells latently infected with HIV-1. This reactivation largely depends on the NF-κB and MAPK signaling pathways because either overexpression of a super-repressor form of IκBα or pretreatment with a MEK inhibitor U0126 diminished provirus reactivation by C1. A pan-PKC inhibitor significantly blocked the phorbol ester-induced but not the C1-induced HIV-1 reactivation. Although C1-induced viral gene expression persisted for as long as 48 h post-stimulation, NF-κB-dependent transcription peaked at 12 h post-stimulation and then quickly declined, suggesting Tat-mediated self-sustainment of HIV-1 expression. These results suggest that procyanidin C1 trimer is a potential compound for reactivation of latent HIV-1 reservoirs.en_US
dc.identifier.otherhttp://dx.doi.org/10.1016/j.bbrc.2015.02.102 .
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/24196
dc.language.isoenen_US
dc.publisherBiochemical and Biophysical Research Communicationsen_US
dc.subjectHIVen_US
dc.subjectLatencyen_US
dc.subjectProcyanidinen_US
dc.subjectReactivationen_US
dc.titleProcyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus.en_US
dc.typeOtheren_US

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Virology Department