Control of Streptococcal Infections: Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniae

Simple item page
dc.contributor.authorBedeley, E.
dc.contributor.authorGori, A.
dc.contributor.authorYeboah-Manu, D.
dc.contributor.authorDiallo, K.
dc.date.accessioned2023-06-26T09:57:10Z
dc.date.available2023-06-26T09:57:10Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractBoth Streptococcus agalactiae [group B streptococcus (GBS)] and Streptococcus pneumoniae (pneumococcus) remain significant pathogens as they cause life threatening infections mostly in children and the elderly. The control of diseases caused by these pathogens is dependent on antibiotics use and appropriate vaccination. The introduction of the pneumococcal conjugate vaccines (PCVs) against some serotypes has led to reduction in pneumococcal infections, however, the subsequent serotype switching, and replacement has been a serious challenge. On the other hand, no vaccine is yet licensed for use in the control of GBS diseases. In this review, we provide an overview of the history and global disease burden, disease pathophysiology and management, vaccines update, and the biology of both pathogens. Furthermore, we address recent findings regarding structural similarities that could be explored for vaccine targets across both mucosal pathogens. Finally, we conclude by proposing future genomic sequence comparison using the wealth of available sequences from both species and the possibility of identifying more related structural components that could be exploited for pan-pathogen vaccine development.en_US
dc.identifier.citationBedeley E, Gori A, Yeboah-Manu D and Diallo K (2021) Control of Streptococcal Infections: Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniae. Front. Microbiol. 12:658824. doi: 10.3389/fmicb.2021.658824en_US
dc.identifier.other10.3389/fmicb.2021.658824
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39400
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.subjectStreptococcus agalactiaeen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectgenome sequenceen_US
dc.subjectvaccineen_US
dc.titleControl of Streptococcal Infections: Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniaeen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Control of Streptococcal Infections Is a Common Vaccine Target Achievable Against Streptococcus agalactiae and Streptococcus pneumoniae.pdf
Size:
2.45 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Bacteriology Department