Klebsiella pneumoniae ST147 harboring blaNDM-1, multidrug resistance and hypervirulence plasmids

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dc.contributor.authorOfosu-Appiah, F.
dc.contributor.authorAcquah, E.E.
dc.contributor.authorMohammed, J.
dc.contributor.authoret al.
dc.date.accessioned2024-04-30T10:09:04Z
dc.date.available2024-04-30T10:09:04Z
dc.date.issued2024
dc.descriptionResearch Articleen_US
dc.description.abstractThe spread of hypervirulent (hv) and carbapenem-/multidrug-resistant Klebsiella pneumoniae is an emerging problem in healthcare settings. The New Delhi metallo-β-lactamase-1 (blaNDM-1) is found in Enterobacteriaceae including K. pneumo niae. The blaNDM-1 is capable of hydrolyzing β-lactam antibiotics which are used for treatment of severe infections caused by multidrug-resistant Gram-negative bacteria. This is associated with the unacceptably high mortality rate in immunocompromised burn injury patients. This study reports on the characterization of blaNDM-1 gene and virulence factors in hv carbapenem-/multidrug-resistant K. pneumoniae ST147 in the burns unit of a tertiary teaching hospital during routine surveillance. Two K. pneumoniae strains were obtained from wounds of burn-infected patients from May 2020 to July 2021. The hypervirulence genes and genetic context of the blaNDM-1 gene and mobile genetic elements potentially involved in the transposition of the gene were analyzed. We identified a conserved genetic background and an IS26 and open reading frame flanking the blaNDM-1 gene that could suggest its involvement in the mobilization of the gene. The plasmid harbored additional antibiotic resistance predicted regions that were responsible for resistance to almost all the routinely used antibiotics. To ensure the identification of potential outbreak strains during routine surveillance, investigations on resistance genes and their environment in relation to evolution are necessary for molecular epidemiology.en_US
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/41740
dc.language.isoenen_US
dc.publisherMicrobiology Spectrumen_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectmultidrug resistanceen_US
dc.subjectmobile genetic elementsen_US
dc.titleKlebsiella pneumoniae ST147 harboring blaNDM-1, multidrug resistance and hypervirulence plasmidsen_US
dc.typeArticleen_US

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