Evaluation Of A Tea Bag Formulation Of Tapinanthus Bangwensis (Engl. And K. Krause) Danser Leaves, Meant For The Management Of Diabetes
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Date
2023
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Scientific African
Abstract
The incorporation of traditional medicine into the mainstream health care delivery system
particularly in some developing countries such as Ghana, has resulted in reliable access to herbal
medicines and their safe use. This has also led to a surge in the search for herbal alternatives.
reformulation, and development of herbal medications in treating and managing diseases such as
diabetes. Currently, the surging price of orthodox antidiabetics and their reported adverse effects
Long-term use has contributed to many Ghanaians switching to the use of phytomedicines as
alternatives. The aim of this study is to formulate tea from the leaves of Tapinanthus bangwensis.
family Loranthaceae to serve as an additional remedy for the management of diabetes.
For standardization, quality control, and authentication of the formulation, FTIR, and HPLC analysis
were conducted. The safety profile of the tea was determined via determination of median lethal dose (LD50), microbial
load, essential elements, and toxic metal contents were also assessed. In addition, the pH and uniformity of
mass, total water extraction, and optimization of the extraction method were also investigated.
The FTIR showed the presence of alcohols, esters, phenols, and aromatic compounds. The HPLC
fingerprint also showed 23 peaks, with the highest peak having a retention time of 15.4 min. The
extract also recorded a pH of 7.43 ± 0.02 at 26.1 ◦C and total water extractive of 39.37 ± 0.05
%w/w. The tea passed the uniformity of mass test with an average net mass of 3.0 ± 0.02 g.
Optimum extraction of the tea was realised with 250 mL of freshly boiled water. The formulated
Tea was found to be safe since the determined LD50 was 50 times more than the daily dose. The
microbial load and elemental and toxic metal contents were also within acceptable limits.
This study has shown the possibility of introducing this tea at a safe dose as an additional
herbal remedy for the management of diabetes.
Description
Research Article
Keywords
Herbal teas, Diabetes and microbial contamination, Phytochemical constituents