SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives

dc.contributor.author	Aniweh, Y.
dc.contributor.author	Nyarko, P.B.
dc.contributor.author	Quansah, E.
dc.contributor.author	Thiam, L.G.
dc.contributor.author	Awandare, G.A.
dc.date.accessioned	2019-05-16T13:24:04Z
dc.date.available	2019-05-16T13:24:04Z
dc.date.issued	2019-03
dc.description.abstract	Recent elucidation of the genetic basis of the Vel blood group system has offered the field of blood transfusion medicine an additional consideration in determining the causes of hemolytic reactions after a patient is transfused. The identification of the SMIM1 gene to be responsible for the Vel blood group allows molecular based tools to be developed to further dissect the function of this antigen. Genetic signatures such as the homozygous 17 bp deletion and the heterozygous 17 bp deletion in combination with other single nucleotide polymorphisms (SNPs) and insertion sequences regulate the expression level of the gene. With this knowledge, it is now possible to study this antigen in-depth.	en_US
dc.identifier.other	https://doi.org/10.1016/j.parepi.2019.e00101
dc.identifier.uri	http://ugspace.ug.edu.gh/handle/123456789/30075
dc.language.iso	en	en_US
dc.publisher	Parasite Epidemiology and Control	en_US
dc.subject	Vel	en_US
dc.subject	Blood	en_US
dc.subject	Nucleotides	en_US
dc.subject	Frameshift	en_US
dc.subject	Heterozygous	en_US
dc.title	SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives	en_US
dc.type	Article	en_US

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