NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis

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dc.contributor.authorAfriyie-Gyawu, E.
dc.contributor.authorWang, Z.
dc.contributor.authorAnkrah, N.A.
dc.contributor.authorXu, L.
dc.contributor.authorJohnson, N.M.
dc.contributor.authorTang, L.
dc.contributor.authorGuan, H.et.al.
dc.date.accessioned2019-04-09T08:52:27Z
dc.date.available2019-04-09T08:52:27Z
dc.date.issued2008-08
dc.description.abstractTo assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day−1 (high dose, HD), 1.5 g NS day−1 (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose–time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 ± 28.00 µg l−1; female = 116.40 ± 24.26 µg l−1) compared with the PL group (male = 83.55 ± 39.90 µg l−1; female = 90.47 ± 25.68 µg l−1) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans. © 2008 Taylor & Francis Group, LLC.en_US
dc.identifier.otherDOI: 10.1080/02652030701854758
dc.identifier.otherVol.25(7): pp 872-84
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29140
dc.language.isoenen_US
dc.publisherFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessmenten_US
dc.subjectAflatoxinen_US
dc.subjectEnterosorbenten_US
dc.subjectHeavy metalsen_US
dc.subjectMicronutrientsen_US
dc.subjectMineralsen_US
dc.subjectNovaSil clayen_US
dc.subjectVitamin Aen_US
dc.subjectVitamin Een_US
dc.titleNovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosisen_US
dc.typeArticleen_US

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