Very late relapses in patients with Burkitt's lymphoma: Clinical and serologic studies.
| dc.contributor.author | Biggar, R.J. | |
| dc.contributor.author | Nkrumah, F.K. | |
| dc.contributor.author | Henle, W. | |
| dc.contributor.author | Levine, P.H. | |
| dc.date.accessioned | 2013-06-12T10:59:50Z | |
| dc.date.accessioned | 2017-10-16T12:58:09Z | |
| dc.date.available | 2013-06-12T10:59:50Z | |
| dc.date.available | 2017-10-16T12:58:09Z | |
| dc.date.issued | 1981 | |
| dc.description.abstract | Of 117 patients in remission for at least 12 months after chemotherapy for confirmed Burkitt's lymphoma, 14 subsequently relapsed. Frequency of ever relapsing in this group varied from 12% 2 years after chemotherapy to 3–8% 3–6 years after chemotherapy. Risk of very late relapse (VLR) increased with the occurrence of meningeal disease and/or relapse before a remission of 12 months or more was achieved. The use of combination chemotherapy and especially prophylactic intrathecal methotrexate significantly lowered the risk of VLR (P<0.03). Serial testing for antibodies to Epstein-Barr viral capsid antigen to the diffuse and restricted components of the early antigen complex and to the Epstein-Barr virus-specific nuclear antigen revealed minor fluctuations but no consistent increases in antibody titers preceding detection of VLR. The serologic follow-up tests thus were not clinically useful for prediction of the imminence of a recurrence. Patients developing VLR generally maintained moderate-to-high titers of antibodies to restricted or diffuse components throughout the long remission periods, which indicated that they were not beyond the danger of a relapse at an unspecified time in the future. | en_US |
| dc.identifier.citation | Biggar, R. J., Nkrumah, F. K., Henle, W., & Levine, P. H. (1981). Very late relapses in patients with burkitt's lymphoma: Clinical and serologic studies. Journal of the National Cancer Institute, 66(3), 439-444. | en_US |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/3084 | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of the National Cancer Institute | en_US |
| dc.title | Very late relapses in patients with Burkitt's lymphoma: Clinical and serologic studies. | en_US |
| dc.type | Article | en_US |