Evaluating circulating soluble markers of endothelial dysfunction and risk factors associated with PE: A multicentre longitudinal case control study in northern Ghana
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Heliyon
Abstract
Serpin E1/PAI-1, N-terminal pro-brain natriuretic peptide (NTpro-BNP) and neuropilin-1 are
markers which have been associated with endothelial dysfunction. However, data on the levels of
these markers in PE is limited. The limited data on the pathophysiology of PE in relation to these
markers necessitated the study.
This was a multicentre case-control study conducted at the Obstetrics and Gynaecology
Department of the Tamale Teaching Hospital, the Bawku Presbyterian Hospital and the Bolgatanga
Regional Hospital. Out of 520 consenting pregnant women, 127 pregnant women met the
inclusion criteria (53 with PE and 74 controls) and were included in this study. Venous, placental,
cord and peripheral blood were collected for biomarker assay, haematological parameters and
placental parasite determination. Placental tissue sections were obtained for placental malaria
and histopathological lesions associated with hypoperfusion. Maternal heart rate and foetal.
Description
Research Article
Keywords
NTpro-BNP, Neuropilin-1, Serpin E1/PAI-1, SD, Eclampsia, Preeclampsia, RI