Modified Halloysite Nanotubes As Vehicle For Sustained Drug Delivery

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Date

2017-07

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University of Ghana

Abstract

Halloysite, a natural mineral mined in many parts of the world has gained a lot of attention recently due to its ability to control and sustain the release of drugs and other active agents. It is a hollow tubular structure composed of double layer of aluminosilicate minerals in the nanometric range. They are non-toxic and biocompatible as compared to other nanocarriers. Its unique structure can be modified to improve its properties for control drug delivery applications. In this study, halloysite nanotubes were modified and the effect of these modifications on sustain drug release was analyzed and evaluated. The two modification techniques employed were acid-treatment and polymer/ halloysite composite formation. After each modification, sodium salicylate drug was loaded and their in vitro release properties were evaluated and compared with raw unmodified halloysite nanotubes. The results obtained indicate that both acid treatment and polymer/halloysite composite formation have no effect on the tubular structure and morphology of halloysite. This was shown by SEM, TEM and FTIR analysis made. However, modification of the halloysite nanotubes influenced the drug release rate. Results obtained also indicate that in acid–treatment modification, there was an improved loading of sodium salicylate drug which resulted in the sustain release of large amount of the sodium salicylate drugs loaded. In polymer/halloysite composite formation, a consistent layer of polymer formed around the halloysite during the composite formation and thus delayed and sustained the release of sodium salicylate drug over a longer period of time as compared to the acid treated and raw untreated halloysite. In both modifications, the in vitro release was best fit with Higuchi model. However, raw untreated halloysite was best fit with Koresymer-Peppas model.

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Thesis (MPhil)

Keywords

Modified, Halloysite Nanotubes, Vehicle, Sustained Drug Delivery

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