High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin

Simple item page
dc.contributor.authorBlankson, S.O.
dc.contributor.authorRietmeyer, L.
dc.contributor.authorTettey, P.
dc.contributor.authorDikroh, L.
dc.contributor.authorAwandare, G.
dc.contributor.authorMensah, B.A.
dc.date.accessioned2023-04-28T20:10:35Z
dc.date.available2023-04-28T20:10:35Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractAmong the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. Our results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria (SNCM) and cerebral malaria (CM). However, the levels of this molecule were found to be higher in patients with severe malarial anemia (SMA) among both CM and SNCM cases (p-value = 0.02). Additionally, the levels of this molecule were found to be higher in patients who died from these pathologies compared to those who survived among the two clinical groups (p-value < 0.0001) and within the same group (p-value < 0.0001 for the CM group, p-value = 0.0046 for the SNCM group). The AUC-ROC for fatality among all the severe cases was 0.77 with a 95%CI of (0.69–0.85). These results suggest that plasma neopterin levels constitute a potential biomarker for predicting fatality among severe falciparum malaria patients.en_US
dc.identifier.citationCitation: Blankson, S.O.; Rietmeyer, L.; Tettey, P.; Dikroh, L.; Tornyigah, B.; Adamou, R.; Moussiliou, A.; Padounou, C.; Amoussou, A.; Mensah, B.A.; et al. High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin. Diagnostics 2023, 13, 528. https://doi.org/10.3390/ diagnostics13030528en_US
dc.identifier.otherhttps://doi.org/10.3390/diagnostics13030528
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/38929
dc.language.isoenen_US
dc.publisherDiagnosticsen_US
dc.subjectneopterinen_US
dc.subjectsevere malariaen_US
dc.subjectcerebral malariaen_US
dc.titleHigh Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Beninen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
High-Plasma-Levels-of-Neopterin-Are-Associated-with-Increased-Mortality-among-Children-with-Severe-Malaria-in-BeninDiagnostics.pdf
Size:
1.78 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

West African Centre for Cell Biology of Infectious Pathogens