High-performance liquid chromatographic assay for the simultaneous determination of sulfadoxine and pyrimethamine from whole blood dried onto filter paper.

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2002

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Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Abstract

A method using solid-phase extraction and high-performance liquid chromatography is evaluated for the simultaneous determination of sulfadoxine and pyrimethamine from 0.1 ml of whole blood dried onto filter paper. Extraction recoveries are about 60% for both drugs. The coefficient of variation for intra-assay precision, inter-assay precision and accuracy is less than 10% for sulfadoxine (10-100 microg/ml) and pyrimethamine (1-10 microg/ml).

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Green, M. D., Mount, D. L., & Nettey, H. (2002). High-performance liquid chromatographic assay for the simultaneous determination of sulfadoxine and pyrimethamine from whole blood dried onto filter paper. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 767(1), 159-162.

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