Re-Thinking “Non-Response” To Wasting Treatment: Exploratory Analysis From 14 Studies.

Abstract

Children who receive therapeutic feeding for wasting treatment but do not reach the anthropometric definitions of recovery (usually within 12–16 weeks) are categorised as ‘non-responders’ and considered as treatment failures. We conducted a pooled analysis to explore the growth trajectories of non-responders and the appropriateness of the definition of ‘non-response’. We pooled 14 studies of children aged 6–59 months receiving treatment for wasting. We included children classified by their studies as recovered or as non-responders. Observing the pooled data of non-responders’ mid-upper arm circumference (MUAC), weight, weight-for-age z-score, weight-for-height z-score and daily weight gain rate, we found that the first quartile differentiated those who did not grow at all versus those that demonstrated some growth. We therefore defined ‘low growth non-responders’ as < 25th percentile anthropometric gain between admission and exit using the non-responders’ pooled study data, and ‘high growth non-responders’ as ≥ 25th percentile gain. We plotted the growth trajectories of MUAC-, weight- and height-related indices of the recovered, high growth and low growth non-responder groups over time using mixed effects generalised additive models. We compared age, sex and anthropometric characteristics of the three groups and explored predictors of non-response category using a multivariate multinomial logistic regression model. For all outcomes, the high-growth non-responders started with a worse anthropometric status compared to those who recovered, but then tracked along a near-parallel growth trajectory. The low-growth non-responders showed limited growth throughout treatment. High growth non-responders are better viewed as ‘delayed responders’ and may need to be kept longer under treatment to recover and reduce the risks from early discharge. Low growth non-responders are the true treatment failures and should be referred for further investigations as quickly as possible. In conclusion, non-responders are not a homogenous group; ~75% of them respond well to treatment and ~25% are treatment failures.