Effect Of Magnesium Sulfate Treatment on Mediators Of Endothelial Dysfunction and Electrolytes in Mild And Severe Preeclampsia: A Case‐Control Study
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley Periodicals LLC
Abstract
Background and Aims: Magnesium sulfate (MgSO4) treatment is widely used for the
prevention of eclamptic seizures. However, its effect on mediators of endothelial
dysfunction (ED) and electrolytes remains unclear. We evaluated the effects of
MgSO4 treatment on mediators of ED and electrolytes.
Methods: We recruited 100 women comprising 50 severe, 50 mild preeclampsia (PE)
as cases and 50 normotensive pregnant women as controls from the Sampa
Government Hospital, Ghana. We estimated for adrenomedullin (AM), calcitonin
gene‐related peptide (CGRP), soluble forms of intercellular adhesion molecule‐1
(sICAM‐1), Na+, K+, and Mg2+ before MgSO4 treatment, 24 h after MgSO4
treatment, and 48 h after delivery. p < 0.05 were considered significant for statistical
analyses.
Results: Levels of AM, sICAM‐1, and Na+ decreased significantly at 24 h after
MgSO4 treatment and 48 h after delivery among PE women compared to the AM
levels before treatment (p < 0.0001). The levels of CGRP and Mg2+ increased
significantly after 24 h of MgSO4 treatment and 48 h after delivery among PE
compared to the AM levels before treatment (p < 0.0001). The changes in AM,
sICAM‐1, CGRP, and Mg2+ at 24 h after treatment and 48 h after delivery were
significantly higher in severe compared to mild PE (p < 0.0001). AM levels reduced
significantly by 14.7% in mild and 42.7% in severe PE after MgSO₄ treatment
(p < 0.05). sICAM‐1 levels reduced significantly by 20.9% in mild and 25% in severe
PE after MgSO₄ treatment. After MgSO₄ treatment, there was significant increase of
42.1% and >100% in CGRP levels in mild and severe PE, respectively (p < 0.05). After
MgSO₄ treatment, Mg²⁺ levels increased significantly by 67.0% and 63.8% in mild
and severe PE, respectively (p < 0.05).
Conclusion: MgSO₄ treatment reduces AM, sICAM‐1, and sodium levels but
improves magnesium and CGRP in severe than mild PE thus have more beneficial
role in severe PE.
Description
Research Article
Keywords
adrenomedullin, calcitonin gene‐related peptide, electrolytes, endothelial, preeclampsia
Citation
Fondjo LA, Sarpong D, Owiredu WKBA, Opoku S, Adu‐Bonsaffoh K, Teviu E. Effect of magnesium sulfate treatment on mediators of endothelial dysfunction and electrolytes in mild and severe preeclampsia: a case‐control study. Health Sci Rep. 2023;6:e1232. doi:10.1002/hsr2.1232