Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria
dc.contributor.author | Kemp, K. | |
dc.contributor.author | Akanmori, B.D. | |
dc.contributor.author | Adabayeri, V. | |
dc.contributor.author | Goka, B.Q. | |
dc.contributor.author | Kurtzhals, J.A.L. | |
dc.contributor.author | Behr, C. | |
dc.contributor.author | Hviid, L. | |
dc.date.accessioned | 2019-02-28T11:58:24Z | |
dc.date.available | 2019-02-28T11:58:24Z | |
dc.date.issued | 2002-01 | |
dc.description.abstract | Available evidence suggests that Plasmodium falciparum malaria causes activation and reallocation of T cells, and that these in vivo primed cells re-emerge into the periphery following drug therapy. Here we have examined the cytokine production capacity and susceptibility to programmed cell death of peripheral T cells during and after the period of antimalarial treatment. A high proportion of peripheral CD3+ cells had an activated phenotype at and shortly after time of admission (day 0) and initiation of therapy. This activation peaked around day 2, and at this time-point peripheral T cells from the patients could be induced to produce cytokines at conditions of limited cytokine response in cells from healthy control donors. Activated CD8hi and TCR-γδ+ cells were the primary IFN-γ producers, whereas CD4+ cells constituted an important source of TNF-α. The proportion of apoptotic T cells was elevated at admission and peaked 2 days later, while susceptibility to activation-induced cell death in vitro remained increased for at least 1 week after admission. Taken together, the data are consistent with the concept of malaria-induced reallocation of activated T cells to sites of inflammation, followed by their release back into the peripheral blood where they undergo apoptotic death to re-establish immunological homeostasis as inflammation subsides. However, the high proportion of pre-apoptotic cells from the time of admission suggests that apoptosis also contributes to the low frequency and number of T cells in the peripheral circulation during active disease. | en_US |
dc.identifier.other | https://doi.org/10.1046/j.1365-2249.2002.01714.x | |
dc.identifier.other | Vol. 127(1): pp 151-7 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/28449 | |
dc.language.iso | en | en_US |
dc.publisher | Clinical and Experimental Immunology | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cytokine | en_US |
dc.subject | Cytometry | en_US |
dc.subject | Flow | en_US |
dc.subject | Malaria | en_US |
dc.title | Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria | en_US |
dc.type | Article | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.6 KB
- Format:
- Item-specific license agreed upon to submission
- Description: