Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria

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dc.contributor.authorKemp, K.
dc.contributor.authorAkanmori, B.D.
dc.contributor.authorAdabayeri, V.
dc.contributor.authorGoka, B.Q.
dc.contributor.authorKurtzhals, J.A.L.
dc.contributor.authorBehr, C.
dc.contributor.authorHviid, L.
dc.date.accessioned2019-02-28T11:58:24Z
dc.date.available2019-02-28T11:58:24Z
dc.date.issued2002-01
dc.description.abstractAvailable evidence suggests that Plasmodium falciparum malaria causes activation and reallocation of T cells, and that these in vivo primed cells re-emerge into the periphery following drug therapy. Here we have examined the cytokine production capacity and susceptibility to programmed cell death of peripheral T cells during and after the period of antimalarial treatment. A high proportion of peripheral CD3+ cells had an activated phenotype at and shortly after time of admission (day 0) and initiation of therapy. This activation peaked around day 2, and at this time-point peripheral T cells from the patients could be induced to produce cytokines at conditions of limited cytokine response in cells from healthy control donors. Activated CD8hi and TCR-γδ+ cells were the primary IFN-γ producers, whereas CD4+ cells constituted an important source of TNF-α. The proportion of apoptotic T cells was elevated at admission and peaked 2 days later, while susceptibility to activation-induced cell death in vitro remained increased for at least 1 week after admission. Taken together, the data are consistent with the concept of malaria-induced reallocation of activated T cells to sites of inflammation, followed by their release back into the peripheral blood where they undergo apoptotic death to re-establish immunological homeostasis as inflammation subsides. However, the high proportion of pre-apoptotic cells from the time of admission suggests that apoptosis also contributes to the low frequency and number of T cells in the peripheral circulation during active disease.en_US
dc.identifier.otherhttps://doi.org/10.1046/j.1365-2249.2002.01714.x
dc.identifier.otherVol. 127(1): pp 151-7
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/28449
dc.language.isoenen_US
dc.publisherClinical and Experimental Immunologyen_US
dc.subjectApoptosisen_US
dc.subjectCytokineen_US
dc.subjectCytometryen_US
dc.subjectFlowen_US
dc.subjectMalariaen_US
dc.titleCytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malariaen_US
dc.typeArticleen_US

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