Identification of Hepatitis B Virus Genotype A/E Recombinants in Ghana

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dc.contributor.authorBoyce, C.L.
dc.contributor.authorWillis, S.
dc.contributor.authorArchampong, T.N.A.
dc.contributor.authorLartey, M.
dc.contributor.authorSagoe, K.W.
dc.contributor.authorObo-Akwa, A.
dc.contributor.authorKenu, E.
dc.contributor.authorKwara, A.
dc.contributor.authorBlackard, J.T.
dc.date.accessioned2019-08-20T08:08:25Z
dc.date.available2019-08-20T08:08:25Z
dc.date.issued2019-07
dc.description.abstractHepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.en_US
dc.identifier.otherDOI: 10.1007/s11262-019-01690-y
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32033
dc.language.isoenen_US
dc.publisherVirus Genesen_US
dc.subjectHepatitis B virusen_US
dc.subjectGenotypeen_US
dc.subjectRecombinant/recombinationen_US
dc.subjectAfricaen_US
dc.subjectGhanaen_US
dc.titleIdentification of Hepatitis B Virus Genotype A/E Recombinants in Ghanaen_US
dc.typeArticleen_US

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