Assessing risk factors for latent and active tuberculosis among persons living with HIV in Florida: A comparison of self-reports and medical records
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
PLOS ONE
Abstract
Purpose
This study examined factors associated with TB among persons living with HIV (PLWH) in
Florida and the agreement between self-reported and medically documented history of
tuberculosis (TB) in assessing the risk factors.
Methods
Self-reported and medically documented data of 655 PLWH in Florida were analyzed. Data
on sociodemographic factors such as age, race/ethnicity, place of birth, current marital status, education, employment, homelessness in the past year and ‘ever been jailed’ and behavioural factors such as excessive alcohol use, marijuana, injection drug use (IDU),
substance and current cigarette use were obtained. Health status information such as health
insurance status, adherence to HIV antiretroviral therapy (ART), most recent CD4 count,
HIV viral load and comorbid conditions were also obtained. The associations between these
selected factors with self-reported TB and medically documented TB diagnosis were compared using Chi-square and logistic regression analyses. Additionally, the agreement
between self-reports and medical records was assessed.
Results
TB prevalence according to self-reports and medical records was 16.6% and 7.5% respectively. Being age 55 years, African American and homeless in the past 12 months were
statistically significantly associated with self-reported TB, while being African American
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PLOS ONE | https://doi.org/10.1371/journal.pone.0271917 August 4, 2022 1 / 12
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OPEN ACCESS
Citation: Seneadza NAH, Kwara A, Lauzardo M,
Prins C, Zhou Z, Se´raphin MN, et al. (2022)
Assessing risk factors for latent and active
tuberculosis among persons living with HIV in
Florida: A comparison of self-reports and medical
records. PLoS ONE 17(8): e0271917. https://doi.
org/10.1371/journal.pone.0271917
Editor: Wenping Gong, The 8th Medical Center of
PLA General Hospital, CHINA
Received: August 30, 2021
Accepted: July 10, 2022
Published: August 4, 2022
Peer Review History: PLOS recognizes the
benefits of transparency in the peer review
process; therefore, we enable the publication of
all of the content of peer review and author
responses alongside final, published articles. The
editorial history of this article is available here:
https://doi.org/10.1371/journal.pone.0271917
Copyright: © 2022 Seneadza et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Data Availability Statement: The data contain
potentially sensitive patient information, but data
can be obtained upon request. Information about
homeless in the past 12 months and not on antiretroviral therapy (ART) were statistically significantly associated with medically documented TB. African Americans compared to Whites
had odds ratios of 3.04 and 4.89 for self-reported and medically documented TB, respectively. There was moderate agreement between self-reported and medically documented
TB (Kappa = 0.41).
Conclusions
TB prevalence was higher based on self-reports than medical records. There was moderate
agreement between the two data sources, showing the importance of self-reports. Establishing the true prevalence of TB and associated risk factors in PLWH for developing policies
may therefore require the use of self-reports and confirmation by screening tests, clinical
signs and/or microbiologic data.
Description
Research Article
Keywords
Persons Living with HIV (PLWH), active tuberculosis, Medical Report, Florida
Citation
Citation: Seneadza NAH, Kwara A, Lauzardo M, Prins C, Zhou Z, Se´raphin MN, et al. (2022) Assessing risk factors for latent and active tuberculosis among persons living with HIV in Florida: A comparison of self-reports and medical records. PLoS ONE 17(8): e0271917. https://doi. org/10.1371/journal.pone.0271917