Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review
Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Phytochemistry Reviews
Abstract
Cyperus rotundus L. has been widely used
in the treatment and prevention of numerous diseases
in traditional systems of medicine around the world,
such as nervous, gastrointestinal systems diseases and
inflammation. In traditional Chinese medicine (TCM),
its rhizomes are frequently used to treat liver disease,
stomach pain, breast tenderness, dysmenorrheal and
menstrual irregularities. The review is conducted to
summarize comprehensively the plant’s vernacular
names, distribution, phytochemistry, pharmacology,
toxicology and analytical methods, along with the data
mining for TCM prescriptions containing C. rotundus.
Herein, 552 compounds isolated or identified from C
rotundus were systematically collated and classified,
concerning monoterpenoids, sesquiterpenoids, flavo noids, phenylpropanoids, phenolics and phenolic
glycosides, triterpenoids and steroids, diterpenoids,
quinonoids, alkaloids, saccharides and others. Their
pharmacological effects on the digestive system,
nervous system, gynecological diseases, and other
bioactivities like antioxidant, anti-inflammatory, anti cancer, insect repellent, anti-microbial activity, etc.
were summarized accordingly. Moreover, except for
the data mining on the compatibility of C. rotundus in
TCM, the separation, identification and analytical
methods of C. rotundus compositions were also
systematically summarized, and constituents of the
essential oils from different regions were re-analyzed
using multivariate statistical analysis. In addition, the
toxicological study progresses on C. rotundus
revealed the safety property of this herb. This review
is designed to serve as a scientific basis and theoretical
reference for further exploration into the clinical use
and scientific research of C. rotundus.
Description
Research Article
Keywords
Cyperi rhizome, Association rules, Gynecological diseases, Sesquiterpenoids