A cross-over trial comparing once daily levobunolol with once and twice daily timolol.

No Thumbnail Available

Date

2005

Journal Title

Journal ISSN

Volume Title

Publisher

European Journal of Ophthalmology

Abstract

The intraocular pressure (IOP) lowering efficacy of once-daily levobunolol 0.5% was compared with timolol 0.5% twice-daily and timolol 0.5% once-daily in 20 chronic open angle glaucoma and 5 ocular hypertensive patients. The design used was a randomised double blind cross-over trial with three periods each of 8 weeks separated by 2 weeks of no treatment. We found that following levobunolol a two week washout was not sufficient for the IOP to return to its original baseline level suggesting that levobunolol is a longer acting drug than timolol. Adjusting for this carryover effect, we found on significant difference in the IOP lowering effect among the three regimes (p = 0.53). Reduced cost, less ocular discomfort and better compliance are the main potential advantages of the once daily treatments.

Description

Keywords

Citation

Akafo, S. K., Thompson, J. R., Rosenthal, A. R. (2005). A cross-over trial comparing once daily levobunolol with once and twice daily timolol. European Journal of Ophthalmology, 5(3), 172-176.

Endorsement

Review

Supplemented By

Referenced By