Impact of an Irrigation Dam on the Transmission and Diversity of Plasmodium falciparum in a Seasonal Malaria Transmission Area of Northern Ghana

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dc.contributor.authorKyei-Baafour, E.
dc.contributor.authorTornyigah, B.
dc.contributor.authorBuade, B.
dc.contributor.authorBimi, L.
dc.contributor.authorOduro, A.R.
dc.contributor.authorKoram, K.A.
dc.contributor.authorGyan, B.A.
dc.contributor.authorKusi, K.A.
dc.date.accessioned2020-06-26T10:48:11Z
dc.date.available2020-06-26T10:48:11Z
dc.date.issued2020-03-19
dc.descriptionResearch Articleen_US
dc.description.abstractWater bodies such as dams are known to alter the local transmission patterns of a number of infectious diseases, especially those transmitted by insects and other arthropod vectors. (e impact of an irrigation dam on submicroscopic asexual parasite carriage in individuals living in a seasonal malaria transmission area of northern Ghana was investigated. A total of 288 archived DNA samples from two cross-sectional surveys in two communities in the Bongo District of Northern Ghana were analysed. Parasite density was determined by light microscopy and PCR, and parasite diversity was assessed by genotyping of the polymorphic Plasmodium falciparum msp2 block-3 region. Submicroscopic parasitaemia was estimated as the proportional difference between positive samples identified by PCR and microscopy. Dry season submicroscopic parasite prevalence was significantly higher (71.0%, p = 0.013) at the dam site compared with the nondam site (49.2%). Similarly, wet season submicroscopic parasite prevalence was significantly higher at the dam site (54.5%, p = 0.008) compared with the nondam site (33.0%). (ere was no difference in parasite density between sites in the dry season (p = 0.90) and in the wet season (p < 0.85). Multiplicity of infection (MOI) based on PCR data was significantly higher at the dam site compared with the nondam site during the dry season (p < 0.0001) but similar between sites during the wet season. MOI at the nondam site was significantly higher in the wet season than in the dry season (2.49, 1.26, p < 0.0001) but similar between seasons at the dam site. Multivariate analysis showed higher odds of carrying submicroscopic parasites at the dam site in both dry season (OR = 7.46, 95% CI = 3.07–18.15) and in wet season (OR = 1.73, 95% CI = 1.04–2.86). (e study findings suggest that large water bodies impact year-round carriage of submicroscopic parasites and sustain Plasmodium transmissionen_US
dc.description.sponsorshipBill and Melinda Gates Foundation under the Postdoctoral and Postgraduate Training in Infectious Diseases Research awarded to the Noguchi Memorial Institute for Medical Research (Global Health Grant number OPP52155).en_US
dc.identifier.otherhttps://doi.org/10.1155/2020/1386587
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/35367
dc.language.isoenen_US
dc.publisherJournal of Tropical Medicineen_US
dc.relation.ispartofseries2020;
dc.subjectmalariaen_US
dc.subjectPlasmodiumen_US
dc.subjectsubmicroscopicen_US
dc.subjectGhanaen_US
dc.titleImpact of an Irrigation Dam on the Transmission and Diversity of Plasmodium falciparum in a Seasonal Malaria Transmission Area of Northern Ghanaen_US
dc.typeArticleen_US

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