Peripheral neuropathy in patients with human immunodeficiency viral infection at a tertiary hospital in Ghana

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dc.contributor.authorPuplampu, P.
dc.contributor.authorGanu, V.
dc.contributor.authorKenu, E.
dc.contributor.authorKudzi, W.
dc.contributor.authorAdjei, P.
dc.contributor.authorGrize, L.
dc.contributor.authorKäser, M.
dc.date.accessioned2019-05-22T15:34:11Z
dc.date.available2019-05-22T15:34:11Z
dc.date.issued2019-04
dc.description.abstractPeripheral neuropathy (PN) is the most frequent neurological complication in people living with HIV/AIDS. Neurological damage was identified to not only be caused by the viral infection itself but also through neurotoxic antiretroviral therapy (ART). PN is associated with a variety of risk factors; however, detailed knowledge is scarce for sub-Saharan African popula- tions, bearing among the highest HIV/AIDS infection burden. In a cross-sectional study, we assessed the prevalence of PN in 525 adult outpatients suffering from HIV/AIDS and admitted to the largest tertiary hospital in Ghana. Through a detailed questionnaire and clinical examination including neurologic assessment and laboratory blood sample testing, this study investigated associations of PN with demographic and health determinants and identified risk factors associated with sensory neuropathy. The prevalence of PN in the Ghanaian cohort was 17.7% and increased odd ratios (OR) when patients were taller (> 1.57 m; OR = 3.84; 95% CI 1.38–10.66) or reached the age > 34 years (p= 0.124). Respondents with longer education duration had significantly less PN (≥9 years of education; OR = 0.49; 95% CI 0.26–0.92). The study also identified significant association of PN to both waist and hip girth and neutrophil counts. Curiously, higher adjusted odd ratios (aOR) of PN of patients under ART treatment were observed when CD4 lymphocytes were elevated (aOR = 0.81; 95% CI 0.36–1.83 and aOR = 2.17; 95% CI 0.93– 5.05, for 300 and 600 counts, respectively). For patients on ART, an increase of 10 CD4 cell count units increased their chance of developing PN by 1% (aOR = 1.01; 95% CI 1.00 to 1.03). Despite current drug application regulations, prevalence of PN is still unacceptably high in sub-Saharan African populations. Reduction in chronic morbidity through a health system with routine monitoring, early diagnosis and prompt intervention, and effective case management can improve people living with HIV/AIDS’quality of life.en_US
dc.identifier.citationPuplampu, P., Ganu, V., Kenu, E. et al. J. Neurovirol. (2019). https://doi.org/10.1007/s13365-019-00743-0en_US
dc.identifier.otherhttps://doi.org/10.1007/s13365-019-00743-0
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30224
dc.language.isoenen_US
dc.publisherJournal of NeuroVirologyen_US
dc.subjectARTen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectBiothesiometeren_US
dc.subjectHIV-AIDSen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjectNRTIen_US
dc.subjectPLHIVen_US
dc.subjectPNen_US
dc.subjectPeople living with HIV/AIDSen_US
dc.subjectPeripheral neuropathyen_US
dc.subjectPrevalenceen_US
dc.subjectProtease inhibitoren_US
dc.subjectSensory neuropathiesen_US
dc.subjectSide effecten_US
dc.titlePeripheral neuropathy in patients with human immunodeficiency viral infection at a tertiary hospital in Ghanaen_US
dc.typeArticleen_US

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