Synthesis and Antimalarial Screening of Derivatives of Benzenesulfonamides

Abstract

Aryl carboxamides are important class of organic compounds with impressive biological activity. A small library of benzenesulphonamides were synthesized via three chemical steps; first by sulfochlorinations of chlorobenzoic acid followed by sulphonamide and amide formation to give the target compounds in high to excellent yields. Preliminary test showed the compounds possess promising in vitro antimalarial activity against the 3D7 strain of the malaria parasite. Regression analysis establish that lipophilicity has more impact on the biological activity than MR and PSA.