Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

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dc.contributor.authorComas, I.
dc.contributor.authorCoscolla, M.
dc.contributor.authorLuo, T.
dc.contributor.authorBorrell, S.
dc.contributor.authorHolt, K.E.
dc.contributor.authorKato-Maeda, M.
dc.contributor.authorParkhill, J.
dc.contributor.authorMalla, B.
dc.contributor.authorBerg, S.
dc.contributor.authorThwaites, G.
dc.contributor.authorYeboah-Manu, D.
dc.contributor.authorBothamley, G.
dc.contributor.authorMei, J.
dc.contributor.authorWei, L.
dc.contributor.authorBentley, S.
dc.contributor.authorHarris, S.R.
dc.contributor.authorNiemann, S.
dc.contributor.authorDiel, R.
dc.contributor.authorAseffa, A.
dc.contributor.authorGao, Q.
dc.contributor.authorYoung, D.
dc.contributor.authorGagneux, S.
dc.date.accessioned2018-12-06T14:20:37Z
dc.date.available2018-12-06T14:20:37Z
dc.date.issued2013-09
dc.description.abstractTuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. Tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities. © 2013 Nature America, Inc. All rights reserved.en_US
dc.identifier.otherDOI: 10.1038/ng.2744
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/26264
dc.language.isoenen_US
dc.publisherNature Geneticsen_US
dc.subjectmigrationen_US
dc.subjectNeolithic co-expansionen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectOut-of-Africaen_US
dc.titleOut-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humansen_US
dc.typeArticleen_US

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