Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs

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dc.contributor.authorAsiedu-Gyekye, I.J.
dc.contributor.authorEdem Kukuia, K.K.
dc.contributor.authorSeidu, A.M.
dc.contributor.authorAntwi-Boasiako, C.
dc.contributor.authorN'guessan, B.B.
dc.contributor.authorFrimpong-Manso, S.
dc.contributor.authorAdjei, S.
dc.contributor.authorZobi, J.
dc.contributor.authorTettey, A.T.
dc.contributor.authorNyarko, A.K.
dc.date.accessioned2019-02-13T15:48:26Z
dc.date.available2019-02-13T15:48:26Z
dc.date.issued2016
dc.description.abstractObjective. This study investigated the elemental composition of unsweetened natural cocoa powder (UNCP), its effect on nitric oxide, and its hepatoprotective potential during simultaneous administration with high-dose artemether/lumefantrine (A/L). Method. Macro- and microelements in UNCP were analyzed with EDXRF spectroscopy. Thirty (30) male Guinea-pigs were then divided into five groups. For groups 3 (low-dose), 4 (medium-dose), and 5 (high-dose), the animals received oral UNCP prophylactically for 14 days. Group 1 received distilled water (14 days) and group 2 A/L for the last 3 days (days 12 to 14). After euthanisation, biochemical and histopathological examinations were carried out in all groups. Results. Phytochemical analysis of UNCP showed the presence of saponins, flavonoids, tannins, and cardiac glycosides. Thirty-eight (38) macro- and microelements were found. UNCP produced significant decreases in ALT, ALP, GGT, and AST levels. A significant increase in total protein levels was observed during A/L+UNCP administration in comparison to 75 mg/kg A/L group. Histopathological examinations buttressed the protective effects of cocoa administration. UNCP administration increased nitric oxide levels 149.71% (P < 0.05) compared to controls. Conclusion. UNCP increases nitric oxide levels and has hepatoprotective potential during A/L administration. A high level of copper was observed which may be detrimental during high daily consumptions of UNCP. © 2016 Isaac Julius Asiedu-Gyekye et al.en_US
dc.identifier.otherhttp://dx.doi.org/10.1155/2016/7387286
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/27509
dc.language.isoenen_US
dc.publisherEvidence-based Complementary and Alternative Medicineen_US
dc.titleUnsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigsen_US
dc.typeArticleen_US

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