The Etiology of Placental Plasmodium Falciparum Malaria in African Women

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dc.contributor.authorOfori, M.F.
dc.contributor.authorLamptey, H.
dc.contributor.authorDickson, E.K.
dc.contributor.authorKyei-Baafour, E.
dc.contributor.authorHviid, L.
dc.date.accessioned2019-07-04T14:10:52Z
dc.date.available2019-07-04T14:10:52Z
dc.date.issued2018-03
dc.description.abstractPlasmodium falciparum parasites causing placental malaria (PM) express the VAR2CSA type of the clonally variant antigen family PfEMP1. This enables evasion of pre-existing immunity and results in placental accumulation of infected erythrocytes (IEs). We present data on seasonal variation in levels of VAR2CSA-specific IgG and IgG specific for a PM-unrelated PfEMP1 protein among Ghanaian women at first antenatal visit. Our results indicate that PM does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on PM incidence, and for antenatal care in woman with pre-existing immunity.en_US
dc.identifier.otherDOI: 10.1093/infdis/jiy168
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/31250
dc.language.isoenen_US
dc.publisherJournal of Infectious Diseasesen_US
dc.subjectIgGen_US
dc.subjectPfEMP1en_US
dc.subjectPlacental malariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectVAR2CSAen_US
dc.titleThe Etiology of Placental Plasmodium Falciparum Malaria in African Womenen_US
dc.typeArticleen_US

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