Formulation and In Vitro Evaluation of Oral Capsules and Suspension from the Ethanolic Extract of Cola nitida Seeds for the Treatment of Diarrhea
Loading...
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Management of diarrhea has evolved over the years from relatively inadequate interventions in the early years to more successful
physiological approaches. The use of herbal medicinal products and supplements has grown significantly over the past three
decades, with more than half of the global population depending on it for some aspect of their primary health care needs. This
study is aimed at formulating solid and liquid oral dosage forms of the ethanolic extract of Cola nitida seeds for the treatment of
diarrhea. The flow property of the dried ethanolic extract was determined and subsequently formulated into granules for
encapsulation. The ethanolic extract was also used in formulating an oral suspension. Pharmacopeia tests such as uniformity of
weight, disintegration, drug content, and dissolution were carried out on the formulated capsules. The formulated suspension
was also assessed using the following parameters; viscosity, flow rate, drug content, dissolution, sedimentation rate, and
sedimentation volume. The dried ethanolic extract and formulated granules exhibited good flow properties. The formulated
capsules exhibited optimal in vitro release of extract (>90% after 45 minutes) and passed the uniformity of weight,
disintegration, and drug content tests. The formulated suspension also passed the drug content test and had a good
sedimentation rate, sedimentation volume, and flow rate. The formulated suspension also exhibited pseudoplastic flow, optimal
viscosity, and a good in vitro release profile (>90% after 45 minutes). Capsules and suspension of the ethanolic extract of Colanitida seeds have been successfully formulated and can be used as standard dosage forms for the management of diarrhea.
Description
Research Articles