Implantable magnetic nanocomposites for the localized treatment of breast cancer

dc.contributor.authorKan-Dapaah, K.
dc.contributor.authorRahbar, N.
dc.contributor.authorSoboyejo, W.
dc.date.accessioned2018-11-19T12:09:06Z
dc.date.available2018-11-19T12:09:06Z
dc.date.issued2014-12
dc.description.abstractArticles you may be interested in Effects of core/shell structure on magnetic induction heating promotion in Fe3O4/γ-Fe2O3 magnetic nanoparticles for hyperthermia Appl. Phys. Lett. 103, 163104 (2013); 10.1063/1.4825270 Effect of the distribution of anisotropy constants on hysteresis losses for magnetic hyperthermia applications Appl. Phys. Lett. 103, 142417 (2013); 10.1063/1.4824649 Size-dependent ferrohydrodynamic relaxometry of magnetic particle imaging tracers in different environments Med. Phys. 40, 071904 (2013); 10.1118/1.4810962 Interface charge transfer in polypyrrole coated perovskite manganite magnetic nanoparticles J. Appl. Phys. 111, 044309 (2012); 10.1063/1.3686662 Poly(caprolactone) based magnetic scaffolds for bone tissue engineering This paper explores the potential of implantable magnetic nanocomposites for the localized treatment of breast cancer via hyperthermia. Magnetite (Fe 3 O 4)-reinforced polydimethylsiloxane composites were fabricated and characterized to determine their structural, magnetic, and thermal properties. The thermal properties and degree of optimization were shown to be strongly dependent on material properties of magnetic nanoparticles (MNPs). The in-vivo temperature profiles and thermal doses were investigated by the use of a 3D finite element method (FEM) model to simulate the heating of breast tissue. Heat generation was calculated using the linear response theory model. The 3D FEM model was used to investigate the effects of MNP volume fraction, nanocomposite geometry, and treatment parameters on thermal profiles. The implications of the results were then discussed for the development of implantable devices for the localized treatment of breast cancer. V C 2014 AIP Publishing LLC.en_US
dc.identifier.citationJournal of Applied Physics 116, 233505 (2014); doi: 10.1063/1.4903736en_US
dc.identifier.otherDOI: 10.1063/1.4903736
dc.identifier.otherVol. 11643(15): p 233505-7
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/25581
dc.language.isoenen_US
dc.publisherJournal of Applied Physicsen_US
dc.subjectImplantable magnetic nanocompositesen_US
dc.subjectbreast canceren_US
dc.subjectlocalized treatmenten_US
dc.titleImplantable magnetic nanocomposites for the localized treatment of breast canceren_US
dc.typeArticleen_US

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