Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol

dc.contributor.authorKlein, L.J.
dc.contributor.authorAyete-Nyampong, J.B.
dc.contributor.authorOppong, S.A.
dc.contributor.authoret al.
dc.date.accessioned2024-01-25T12:45:58Z
dc.date.available2024-01-25T12:45:58Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractIn pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition on pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: CRD42023429412.en_US
dc.identifier.otherhttps://doi.org/10.3390/mps6050088
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/41144
dc.language.isoenen_US
dc.publisherMethods and Protocolsen_US
dc.subjectsickle cell anemiaen_US
dc.subjectpregnancyen_US
dc.subjectnutritional statusen_US
dc.titleEpidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocolen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Epidemiology-of-Maternal-Nutritional-Status-and-Risk-of-Adverse-Birth-Outcomes-in-Undernourished-Mothers-with-Sickle-Cell-Disease-A-Systematic-Review-and-MetaAnalysis-ProtocolMethods-and-Protocols.pdf
Size:
259.08 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: