Nasopharyngeal carriage of Streptococcus pneumoniae among healthy children in Kassena-Nankana districts of Northern Ghana

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dc.contributor.authorNarwortey, D.K.
dc.contributor.authorOwusu-Ofori, A.
dc.contributor.authorSlotved, H-C.
dc.contributor.authorDonkor4, E.S.
dc.contributor.authorAnsah, P.O.
dc.contributor.authorWelaga, P.
dc.contributor.authorAgongo, G.
dc.contributor.authorOduro, A.R.
dc.date.accessioned2021-09-24T16:42:31Z
dc.date.available2021-09-24T16:42:31Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Pneumococcal vaccine immunizations may be responsible for alterations in serotype epidemiology within a region. This study investigated the pneumococcal carriage prevalence and the impact of the 13-valent pneumococcal conjugate vaccine (PCV-13) on circulating serotypes among healthy children in Northern Ghana. Methods: This was a cross sectional study conducted in the Kassena-Nankana districts of Northern Ghana from November to December during the dry season of 2018. Nasopharyngeal swabs collected from 193 participants were cultured per standard microbiological protocols and pneumococcal isolates were serotyped using the latex agglutination technique and the capsular Quellung reaction test. We examined for any association between the demographic characteristics of study participants and pneumococcal carriage using chi-square test and logistic regression. Results: Of the 193 participants that were enrolled the mean age was 8.6 years and 54.4% were females. The carriage rate among the participants was 32.6% (63/193), and twenty different serotypes were identified. These included both vaccine serotypes (VT), 35% (7/20) and non-vaccine serotypes (NVT), 65% (13/20). The predominant serotypes (34 and 11A), both of which were NVT, accounted for a prevalence of 12.8%. PCV-13 covered only 35% of serotypes identified whiles 40% of serotypes are covered by PPV 23. Conclusion: Post-vaccination carriage of S. pneumoniae is high and is dominated by non-vaccine serotypes. There is therefore a need for the conduct of invasive pneumococcal disease surveillance (IPD) to find out if the high nonvaccine serotype carriage translates to disease. And in addition, a review of the currently used PCV-13 vaccine in the country would be considered relevant.en_US
dc.identifier.otherhttps://doi.org/10.1186/s12879-021-06302-5
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/36759
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectS. pneumoniaeen_US
dc.subjectPCV-13en_US
dc.subjectCarriageen_US
dc.subjectVaccine serotypesen_US
dc.subjectNon-vaccine serotypesen_US
dc.subjectNorthern Ghanaen_US
dc.titleNasopharyngeal carriage of Streptococcus pneumoniae among healthy children in Kassena-Nankana districts of Northern Ghanaen_US
dc.typeArticleen_US

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