Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

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dc.contributor.authorAdu, B.
dc.contributor.authorJepsen, M.P.G.
dc.contributor.authorGerds, T.A.
dc.contributor.authorKyei-Baafour, E.
dc.contributor.authorChristiansen, M.
dc.contributor.authorDodoo, D.
dc.contributor.authorTheisen, M.
dc.date.accessioned2018-11-05T09:08:48Z
dc.date.available2018-11-05T09:08:48Z
dc.date.issued2014
dc.description.abstractImmunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies. © The Author 2013.en_US
dc.identifier.other10.1093/infdis/jit422
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/25239
dc.language.isoenen_US
dc.publisherJournal of Infectious Diseasesen_US
dc.subjectEffect modificationen_US
dc.subjectFcγRIIIBen_US
dc.subjectFCGR3B-c.233C>Aen_US
dc.subjectGLURPen_US
dc.subjectMalariaen_US
dc.subjectNeutrophilsen_US
dc.subjectPlasmodium falciparumen_US
dc.titleFc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian childrenen_US
dc.typeArticleen_US

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