Annickia polycarpa extract attenuates inflammation, neutrophil recruitment, and colon damage during colitis

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dc.contributor.authorLartey, N.L.
dc.contributor.authorVargas-Robles, H.
dc.contributor.authorGuerrero-Fonseca, I.M.
dc.contributor.authorNava, P.
dc.contributor.authorKumatia, E.K.
dc.contributor.authorOcloo, A.
dc.contributor.authorSchnoor, M.
dc.date.accessioned2022-10-03T12:04:38Z
dc.date.available2022-10-03T12:04:38Z
dc.date.issued2022
dc.descriptionResearch Articleen_US
dc.description.abstractInflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are complex inflammatory disorders of the digestive tract. Dysfunctional intestinal epithelial barrier, uncontrolled neutrophil recruitment into the colon, and oxidative stress are major features of IBD. IBD cannot be cured, but symptoms can be alleviated with anti-inflammatory drugs, which often show adverse effects. Thus, safer alternative treatment options are needed. Given the known anti-inflammatory properties of Annickia polycarpa extract (APE), we hy pothesized that APE improves the outcome of the inflammatory response during colitis. We assessed APE effects on colon histology, epithelial barrier function and neutrophil recruitment during DSS-induced colitis in mice treated with APE. APE treatment significantly reduced the disease activity index and prevented DSS-induced colon damage as evidenced by reduced colon shortening, ulcerations, crypt dysplasia, edema formation, and leukocyte infiltration. Expression of the pro-inflammatory cytokines TNF-α, IL-6, and IL-1β were significantly diminished in APE-treated mice. Importantly, APE administration reduced neutrophil infiltration into the lamina propria leading to reduced oxidative stress, tight junction disruption and epithelial permeability in the colon. Thus, we propose APE as additional treatment strategy to attenuate colitis symptoms and enhance life quality of individuals with IBD.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.imlet.2022.07.006
dc.identifier.urihttp://localhost:8080/handle/123456789/38318
dc.language.isoenen_US
dc.publisherImmunology Lettersen_US
dc.subjectInflammatory bowel diseasesen_US
dc.subjectUlcerative colitisen_US
dc.subjectNutritional supplementen_US
dc.subjectE--cadherinen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectZO-1en_US
dc.titleAnnickia polycarpa extract attenuates inflammation, neutrophil recruitment, and colon damage during colitisen_US
dc.typeArticleen_US

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