Biochemical markers of nephrotic syndrome: An observational, cross-sectional study

dc.contributor.authorOfori, E.K.
dc.contributor.authorClinton, E.B.
dc.contributor.authorAcheampong, O.D.
dc.contributor.authorAsare- Anane, H.
dc.contributor.authoret al.
dc.date.accessioned2023-05-16T12:15:59Z
dc.date.available2023-05-16T12:15:59Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Blood protein leakage, especially albumin, into the urine is the hallmark of nephrotic syndrome (NS), which poses a serious public health problem. The absence of albumin prompts the liver to produce more proteins to make up the difference. The therapeutic significance of these additional proteins in NS is not yet fully understood. Methods: In total, 99 patients with NS and 47 persons without NS (control group) were included in this cross-sectional study. Socio-demographic and clinical information were obtained from recruits utilizing a standard questionnaire and a check of the lab order forms for individuals. Each participant had a 6-mL (6 mL) sample of venous blood taken and levels of calcium, C-reactive protein (CRP), albumin, and other proteins in the serum were assayed. The proteins in serum were separated using the electrophoresis technique, and the various fractions were then measured by a densitometer. Calculations were made for the oncotic pressure. Results: The NS group had significantly greater levels of serum CRP, urea, alpha-2-globulin, gamma globulins, and M component than the control group (p < 0.05 respectively). Transferrin, total proteins, albumin, beta-1-globulins, calcium, and oncotic pressure were significantly higher in persons without NS compared to the NS group (p < 0.05 respectively). In addition, levels of CRP (odds ratio = 1.41, p = 0.005) and gamma globulin (odds ratio = 4.12, p = 0.005) in the blood were observed to be independent predictors in the occurrence of NS. These two factors increased the likelihood of developing NS by approximately 1.5 and 4 times, respectively. Conclusion: Among the proteins assayed, CRP and gamma globulin were found to be predictors of NS. Nonetheless, further studies are required to understand the mechanisms associated with these serum proteins in NS.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.heliyon.2023.e15198
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39062
dc.language.isoenen_US
dc.publisherHeliyonen_US
dc.subjectNephrotic syndromeen_US
dc.subjectAlbuminen_US
dc.subjectElectrophoresisen_US
dc.titleBiochemical markers of nephrotic syndrome: An observational, cross-sectional studyen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Biochemical markers of nephrotic syndrome An observational,.pdf
Size:
336.2 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: