Assessment of the performance of haematological and non-invasive fbrotic indices for the monitoring of chronic HBV infection: a pilot study in a Ghanaian populatio

Abstract

Objective Haematological and liver fbrotic markers could be appreciably utilized for efective monitoring of Chronic Hepatitis B viral (HBV) infection, thereby increasing patient’s treatment outcome. The objective of this study was to assess the applicability of complete blood count (CBC) and non-invasive liver-fbrotic indices as markers of prognostic outcome and monitoring in HBV infections. Results Signifcant diferences in levels of white cell and diferentials counts, red blood cell count, hemoglobin indices, and platelet indices were observed between HBV-infected patients (cases) and uninfected persons (controls). Levels of haemoglobin (Hb), total white blood cells (tWBC), neutrophils, monocytes, platelets, and Platelet Distribution width (PDW) were signifcantly lower (p<0.05) in the cases compared to the controls. Total and indirect bilirubin; De Ritis ratio, Aspartate transaminase to platelet ratio index (APRI) and RDW-to-platelet ratio (RPR) were elevated in cases compared with controls (p-value<0.05). In a multivariate adjusted model to test the signifcance of markers, Hemo globin Index (beta coefcient=− 0.876, p-value<0.001), NLR (beta coefcient=− 0.839, p-value<0.001), MPV_10000 (beta coefcient=− 0.333, p-value<0.001) and Albumin (beta coefcient=− 0.059, p-value=0.014), were associated with HBV infection status. Receiver operative characteristics curve analysis showed Hemoglobin Index (AUC=0.744) and MPV_10000 (AUC=0.730) as better prognostic markers for HBV-infection.