Genomic Epidemiological Analysis Identifies High Relapse among Individuals with Recurring Tuberculosis and Provides Evidence of Recent Household-Related Transmission of Tuberculosis in Ghana

dc.contributor.authorAsare, P.
dc.contributor.authorOsei-Wusu, S.
dc.contributor.authorBaddoo, N.A.
dc.contributor.authoret al.
dc.date.accessioned2023-06-26T09:36:24Z
dc.date.available2023-06-26T09:36:24Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractObjective: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. Methods: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis carried out to assess strain relatedness. Results: The majority (58.3%, 21/36) of study participants with rcTB episodes had TB recurrence within 12 months post treatment. TB strains with isoniazid (INH) resistance were found in 19.4% (7/36) of participants at the primary episode, of which 29% (2/7) were also rifampicin-resistant. On TB recurrence, an INH-resistant strain was found in a larger proportion of participants, 27.8% (10/36), of which 40% (4/10) were MDR-TB strains. rcTB was attributed to relapse (same strain) in 75.0% (27/36) of participants and 25.0% (9/36) to re-infection. Conclusion: Our findings indicate that previous unresolved infection due to inadequate treatment, may be the major cause of rcTB.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.ijid.2021.02.110
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39376
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectMycobacterium africanumen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectWhole-genome sequencingen_US
dc.subjectTuberculosisen_US
dc.titleGenomic Epidemiological Analysis Identifies High Relapse among Individuals with Recurring Tuberculosis and Provides Evidence of Recent Household-Related Transmission of Tuberculosis in Ghanaen_US
dc.typeArticleen_US

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