The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
dc.contributor.author | Ghansah, A. | |
dc.contributor.author | Verity, R. | |
dc.contributor.author | Aydemir, O. | |
dc.contributor.author | Brazeau, N.F. | |
dc.contributor.author | Watson, O.J. | |
dc.contributor.author | Hathaway, N.J. | |
dc.contributor.author | Mwandagalirwa, M.K. | |
dc.contributor.author | Marsh, P.W. | |
dc.contributor.author | Thwai, K. | |
dc.contributor.author | Fulton, T. | |
dc.contributor.author | Denton, M. | |
dc.contributor.author | Morgan, A.P. | |
dc.contributor.author | Parr, J.B. | |
dc.contributor.author | Tumwebaze, P.K. | |
dc.contributor.author | Conrad, M. | |
dc.contributor.author | Rosenthal, P.J. | |
dc.contributor.author | Ishengoma, D.S. | |
dc.contributor.author | Ngondi, J. | |
dc.contributor.author | Gutman, J. | |
dc.contributor.author | Mulenga, M. | |
dc.contributor.author | Norris, D.E. | |
dc.contributor.author | Moss, W.J. | |
dc.contributor.author | Mensah, B.A. | |
dc.contributor.author | Myers-Hansen, J.L. | |
dc.contributor.author | Tshefu, A.K. | |
dc.contributor.author | Ghani, A.C. | |
dc.contributor.author | Meshnick, S.R. | |
dc.contributor.author | Bailey, J.A. | |
dc.contributor.author | Juliano, J.J. | |
dc.date.accessioned | 2020-07-29T12:40:40Z | |
dc.date.available | 2020-07-29T12:40:40Z | |
dc.date.issued | 2020-04-30 | |
dc.description | Research Article | en_US |
dc.description.abstract | The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations. | en_US |
dc.description.sponsorship | National Institutes of Health (R01AI107949, R01AI139520, K24AI134990, R21AI121465, F30AI143172, U19AI089680). R.V is funded by a Skills Development Fellowship: this award is jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 programme supported by the European Union | en_US |
dc.identifier.citation | Verity, R., Aydemir, O., Brazeau, N.F. et al. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun 11, 2107 (2020). https://doi.org/10.1038/s41467-020-15779-8 | en_US |
dc.identifier.other | https://doi.org/10.1038/s41467-020-15779-8 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/35735 | |
dc.language.iso | en | en_US |
dc.publisher | Nature Communications | en_US |
dc.relation.ispartofseries | 11; | |
dc.subject | Democratic Republic of the Congo (DRC) | en_US |
dc.subject | malaria | en_US |
dc.subject | Plasmodium falciparum infections | en_US |
dc.subject | sulfadoxine-pyrimethamine | en_US |
dc.title | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC | en_US |
dc.type | Article | en_US |
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