The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

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dc.contributor.authorGhansah, A.
dc.contributor.authorVerity, R.
dc.contributor.authorAydemir, O.
dc.contributor.authorBrazeau, N.F.
dc.contributor.authorWatson, O.J.
dc.contributor.authorHathaway, N.J.
dc.contributor.authorMwandagalirwa, M.K.
dc.contributor.authorMarsh, P.W.
dc.contributor.authorThwai, K.
dc.contributor.authorFulton, T.
dc.contributor.authorDenton, M.
dc.contributor.authorMorgan, A.P.
dc.contributor.authorParr, J.B.
dc.contributor.authorTumwebaze, P.K.
dc.contributor.authorConrad, M.
dc.contributor.authorRosenthal, P.J.
dc.contributor.authorIshengoma, D.S.
dc.contributor.authorNgondi, J.
dc.contributor.authorGutman, J.
dc.contributor.authorMulenga, M.
dc.contributor.authorNorris, D.E.
dc.contributor.authorMoss, W.J.
dc.contributor.authorMensah, B.A.
dc.contributor.authorMyers-Hansen, J.L.
dc.contributor.authorTshefu, A.K.
dc.contributor.authorGhani, A.C.
dc.contributor.authorMeshnick, S.R.
dc.contributor.authorBailey, J.A.
dc.contributor.authorJuliano, J.J.
dc.date.accessioned2020-07-29T12:40:40Z
dc.date.available2020-07-29T12:40:40Z
dc.date.issued2020-04-30
dc.descriptionResearch Articleen_US
dc.description.abstractThe Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations.en_US
dc.description.sponsorshipNational Institutes of Health (R01AI107949, R01AI139520, K24AI134990, R21AI121465, F30AI143172, U19AI089680). R.V is funded by a Skills Development Fellowship: this award is jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 programme supported by the European Unionen_US
dc.identifier.citationVerity, R., Aydemir, O., Brazeau, N.F. et al. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun 11, 2107 (2020). https://doi.org/10.1038/s41467-020-15779-8en_US
dc.identifier.otherhttps://doi.org/10.1038/s41467-020-15779-8
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/35735
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.relation.ispartofseries11;
dc.subjectDemocratic Republic of the Congo (DRC)en_US
dc.subjectmalariaen_US
dc.subjectPlasmodium falciparum infectionsen_US
dc.subjectsulfadoxine-pyrimethamineen_US
dc.titleThe impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRCen_US
dc.typeArticleen_US

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