Polymorphisms in interleukin-1 β and interleukin-1 receptor antagonist genes and malaria in Ghanaian children

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dc.contributor.authorGyan, B.
dc.contributor.authorGoka, B.
dc.contributor.authorCvetkovic, J.T.
dc.contributor.authorPerlmann, H.
dc.contributor.authorLefvert, A.-K.
dc.contributor.authorAkanmori, B.
dc.contributor.authorTroye-Blomberg, M.
dc.date.accessioned2019-02-28T10:16:13Z
dc.date.available2019-02-28T10:16:13Z
dc.date.issued2002-12
dc.description.abstractWe have investigated the possible associations between polymorphisms in two interleukin-1 (IL-1) genes and severity of Plasmodium falciparum malaria in Ghanaian children with cerebral malaria, severe anaemia or uncomplicated malaria and controls. There was no significant difference in genotype and allele frequencies in IL-1 β exon 5 or interleukin-1 receptor antagonist (IL-1ra) polymorphisms between the studied groups, suggesting that the two polymorphisms may not be involved in the pathogenesis of severe malaria. When parasitaemias in uncomplicated malaria patients were evaluated, a significantly higher level of parasitaemia was observed among carriers of IL-1 β A2 allele as compared with noncarriers of this allele (P = 0.01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1 β exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria.en_US
dc.identifier.otherhttps://doi.org/10.1046/j.1365-3083.2002.01161.x
dc.identifier.otherVolume 56, Issue 6, Pages 619-622
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/28441
dc.language.isoenen_US
dc.publisherScandinavian Journal of Immunologyen_US
dc.titlePolymorphisms in interleukin-1 β and interleukin-1 receptor antagonist genes and malaria in Ghanaian childrenen_US
dc.typeArticleen_US

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