Association between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility: An updated systematic review and meta-analyses

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dc.contributor.authorWang, H.
dc.contributor.authorZhang, X.
dc.contributor.authorWu, W.
dc.contributor.authorZhang, M.
dc.contributor.authorSam, N.B.
dc.contributor.authorNiu, L.
dc.date.accessioned2019-06-20T09:08:59Z
dc.date.available2019-06-20T09:08:59Z
dc.date.issued2018-11
dc.description.abstractObjectives: Association between the D-repeat of asporin (ASPN) gene and osteoarthritis (OA) was still inconsistent. We performed this meta-analysis to systematically assess the D-repeat polymorphisms in OA susceptibility. Methods: Relevant studies were enrolled by searching databases. Odd ratios (ORs) with 95% confidence intervals (95% CIs) were used for evaluating the association between ASPN gene and OA. Heterogeneity was calculated using the Q statistic, and three different subgroup analyses were performed on ethnicity, gender, and OA positions respectively. False discovery rate (FDR) was applied to regulate the multiple comparisons. Results: Twelve qualified articles involving 5190 OA patients and 5167 healthy controls were included. With D13 polymorphism, Caucasian male patients have low OA susceptibility (P = .008, PFDR = .024, OR [95% CI] = 0.83 [0.73-0.95]). As to D14 polymorphism, all male patients (P = .0004, PFDR = .001, OR [95% CI] = 1.38 [1.15-1.64]), Asian male patients (P = .01, PFDR = .01, OR [95% CI] = 1.72 [1.11-2.66]), and Caucasian male patients (P = .005, PFDR = .001, OR [95% CI] = 1.32 [1.09-1.60]) have high OA susceptibility. In the pooled-population of KOA with D14 polymorphism, overall male patients (P = .03, PFDR = .045, OR [95% CI] = 1.35 [1.02-1.78]) and Asian male patients (P = .01, PFDR = .03, OR [95% CI] = 1.72 [1.11-2.66]) have high OA risk. With D16 polymorphism, Latin America patients may have high OA risk (P = .04, PFDR = .15, OR [95% CI] = 1.43 [1.02-2.01]). Conclusion: Our results suggest that D-repeat of ASPN gene is mainly associated with male patients. The D13 polymorphism plays a protective role for OA in Caucasians male individuals while D14 plays a risk factor for KOA in male patients.en_US
dc.identifier.otherDOI: 10.1097/MD.0000000000013163
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30988
dc.language.isoenen_US
dc.publisherMedicine (United States)en_US
dc.subjectAsporinen_US
dc.subjectMeta-analysisen_US
dc.subjectOsteoarthritisen_US
dc.subjectPolymorphismen_US
dc.titleAssociation between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility: An updated systematic review and meta-analysesen_US
dc.typeArticleen_US

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