Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children
dc.contributor.author | Mitchell, N.J. | |
dc.contributor.author | Kumi, J. | |
dc.contributor.author | Aleser, M. | |
dc.contributor.author | Elmore, S.E. | |
dc.contributor.author | Rychlik, K.A. | |
dc.contributor.author | Zychowski, K.E. | |
dc.contributor.author | Romoser, A.A. | |
dc.contributor.author | Phillips, T.D. | |
dc.contributor.author | Ankrah, N.-A. | |
dc.date.accessioned | 2018-11-23T09:58:09Z | |
dc.date.available | 2018-11-23T09:58:09Z | |
dc.date.issued | 2014-08 | |
dc.description.abstract | Recently, an association between childhood growth stunting and aflatoxin (AF) exposure has been identified. In Ghana, homemade nutritional supplements often consist of AF-prone commodities. In this study, children were enrolled in a clinical intervention trial to determine the safety and efficacy of Uniform Particle Size NovaSil (UPSN), a refined calcium montmorillonite known to be safe in adults. Participants ingested 0.75 or 1.5 g UPSN or 1.5 g calcium carbonate placebo per day for 14 days. Hematological and serum biochemistry parameters in the UPSN groups were not significantly different from the placebo-controlled group. Importantly, there were no adverse events attributable to UPSN treatment. A significant reduction in urinary metabolite (AFM1) was observed in the high-dose group compared with placebo. Results indicate that UPSN is safe for children at doses up to 1.5 g/day for a period of 2 weeks and can reduce exposure to AFs, resulting in increased quality and efficacy of contaminated foods. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene. | en_US |
dc.identifier.other | DOI: 10.4269/ajtmh.14-0093 | |
dc.identifier.other | Vol. 91(4), 2014, pp. 777–785 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/25724 | |
dc.language.iso | en | en_US |
dc.publisher | American Journal of Tropical Medicine and Hygiene | en_US |
dc.subject | Short-Term Safety | en_US |
dc.subject | Calcium | en_US |
dc.subject | Montmorillonite Clay | en_US |
dc.subject | Uniform Particle Size NovaSil (UPSN) | en_US |
dc.subject | Children | en_US |
dc.title | Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children | en_US |
dc.type | Article | en_US |
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