Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children

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dc.contributor.authorMitchell, N.J.
dc.contributor.authorKumi, J.
dc.contributor.authorAleser, M.
dc.contributor.authorElmore, S.E.
dc.contributor.authorRychlik, K.A.
dc.contributor.authorZychowski, K.E.
dc.contributor.authorRomoser, A.A.
dc.contributor.authorPhillips, T.D.
dc.contributor.authorAnkrah, N.-A.
dc.date.accessioned2018-11-23T09:58:09Z
dc.date.available2018-11-23T09:58:09Z
dc.date.issued2014-08
dc.description.abstractRecently, an association between childhood growth stunting and aflatoxin (AF) exposure has been identified. In Ghana, homemade nutritional supplements often consist of AF-prone commodities. In this study, children were enrolled in a clinical intervention trial to determine the safety and efficacy of Uniform Particle Size NovaSil (UPSN), a refined calcium montmorillonite known to be safe in adults. Participants ingested 0.75 or 1.5 g UPSN or 1.5 g calcium carbonate placebo per day for 14 days. Hematological and serum biochemistry parameters in the UPSN groups were not significantly different from the placebo-controlled group. Importantly, there were no adverse events attributable to UPSN treatment. A significant reduction in urinary metabolite (AFM1) was observed in the high-dose group compared with placebo. Results indicate that UPSN is safe for children at doses up to 1.5 g/day for a period of 2 weeks and can reduce exposure to AFs, resulting in increased quality and efficacy of contaminated foods. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.en_US
dc.identifier.otherDOI: 10.4269/ajtmh.14-0093
dc.identifier.otherVol. 91(4), 2014, pp. 777–785
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/25724
dc.language.isoenen_US
dc.publisherAmerican Journal of Tropical Medicine and Hygieneen_US
dc.subjectShort-Term Safetyen_US
dc.subjectCalciumen_US
dc.subjectMontmorillonite Clayen_US
dc.subjectUniform Particle Size NovaSil (UPSN)en_US
dc.subjectChildrenen_US
dc.titleShort-term safety and efficacy of calcium montmorillonite clay (UPSN) in childrenen_US
dc.typeArticleen_US

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