Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer

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dc.contributor.authorAmissah, N.A.
dc.contributor.authorChlebowicz, M.A.
dc.contributor.authorAblordey, A.
dc.contributor.authorSabat, A.J.
dc.contributor.authorTetteh, C.S.
dc.contributor.authorPrah, I.
dc.contributor.authorvan der Werf, T.S.
dc.contributor.authorFriedrich, A.W.
dc.contributor.authorvan Dijl, J.M.
dc.contributor.authorRossen, J.W.
dc.contributor.authorStienstra, Y.
dc.date.accessioned2017-11-01T12:17:41Z
dc.date.available2017-11-01T12:17:41Z
dc.date.issued2015
dc.description.abstractBackground: Buruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. The wounds of most BU patients are colonized with different microorganisms, including Staphylococcus aureus. Methodology: This study investigated possible patient-to-patient transmission events of S. aureus during wound care in a health care center. S. aureus isolates from different BU patients with overlapping visits to the clinic were whole-genome sequenced and analyzed by a gene-by-gene approach using SeqSphere+ software. In addition, sequence data were screened for the presence of genes that conferred antibiotic resistance. Principal Findings: SeqSphere+ analysis of whole-genome sequence data confirmed transmission of methicillin resistant S. aureus (MRSA) and methicillin susceptible S. aureus among patients that took place during wound care. Interestingly, our sequence data show that the investigated MRSA isolates carry a novel allele of the fexB gene conferring chloramphenicol resistance, which had thus far not been observed in S. aureus. © 2015 Amissah et al.en_US
dc.identifier.issn19352727
dc.identifier.other10.1371/journal.pntd.0004049
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/22401
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleMolecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulceren_US
dc.typeArticleen_US

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