Evaluating antidisease immunity to malaria and implications for vaccine design
Files
Date
2017-11
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
IMMUNOLOGY
Abstract
Immunity to malaria could be categorized broadly as antiparasite or
antidisease immunity. While most vaccine research efforts have focused
on antiparasite immunity, the evidence from endemic populations suggest
that antidisease immunity is an important component of natural immunity
to malaria. The processes that mediate antidisease immunity have,
however, attracted little to no attention, and most interests have been
directed towards the antibody responses. This review evaluates the evidence
for antidisease immunity in endemic areas and discusses the possible
mechanisms responsible for it. Given the key role that inflammation
plays in the pathogenesis of malaria, regulation of the inflammatory
response appears to be a major mechanism for antidisease immunity in
naturally exposed individuals.
Description
Keywords
inflammation, malaria, tolerance