Novel Strategies for Malaria Vaccine Design

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dc.contributor.authorFrimpong, A.
dc.contributor.authorKusi, K.A.
dc.contributor.authorOfori, M.F.
dc.contributor.authorNdifon, W.
dc.date.accessioned2019-06-17T11:49:00Z
dc.date.available2019-06-17T11:49:00Z
dc.date.issued2018-11
dc.description.abstractThe quest for a licensed effective vaccine against malaria remains a global priority. Even though classical vaccine design strategies have been successful for some viral and bacterial pathogens, little success has been achieved for Plasmodium falciparum, which causes the deadliest form of malaria due to its diversity and ability to evade host immune responses. Nevertheless, recent advances in vaccinology through high throughput discovery of immune correlates of protection, lymphocyte repertoire sequencing and structural design of immunogens, provide a comprehensive approach to identifying and designing a highly efficacious vaccine for malaria. In this review, we discuss novel vaccine approaches that can be employed in malaria vaccine design.en_US
dc.identifier.otherhttps://doi.org/10.3389/fimmu.2018.02769
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30827
dc.language.isoenen_US
dc.publisherFrontiers in Immunologyen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectMalariaen_US
dc.subjectVaccineen_US
dc.subjectImmunoinformaticsen_US
dc.subjectStructure-baseden_US
dc.subjectLymphocyte repertoire sequencingen_US
dc.titleNovel Strategies for Malaria Vaccine Designen_US
dc.typeArticleen_US

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