Predictors of post-operative outcomes in patients with peripheral arterial disease and critical limb ischaemia: a systematic review and meta-analysis

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dc.contributor.authorWu, L.P.
dc.contributor.authorNaidoo, N.G.
dc.contributor.authorAdetokunboh, O.O.
dc.date.accessioned2021-12-21T13:45:01Z
dc.date.available2021-12-21T13:45:01Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: A very small proportion (1%) of patients with peripheral artery disease (PAD) present with critical limb threatening ischaemia (CLTI) with poor prognosis. The present review showcased several pre-operative predictors and key post-operative outcomes. Identification of any modifiable predictors may impact positively on surgical out comes. Design: PubMed/Medline, Google scholar and Cochrane databases were searched using terms such as “peripheral arterial disease” AND “critical limb ischemia,” “post-operative outcome,” AND “predictors of post-operative out comes”. Search was for relevant English-language articles published between January 1997 and December 2007 Se lected articles were screened first by title and abstract, and selection of full articles was based on relevance using our inclusion and exclusion criteria and quality ratings performed with the MINORS score. Results: The included studies were published between 1997 and 2007. Only six (6) articles out of a total of 2,114 were deemed suitable for analysis. Ambulatory recovery was >70% at six months, 86.7% and 70.0% at one year and five years respectively. Rate of local wound complications was between 12% and 24%. Reported limb salvage rates were >90% at six months, >70% at one year and 70.0-90.0% at five years. Primary graft patency rate at one year ranged from 63% and 76.6%. Gangrene, diabetes and impaired pre-operative ambulatory function are associated with more wound complications, low limb salvage, reduced graft patency and poor functional outcome. Conclusion: Pre-operative ambulatory status was the most important predictor of post-operative ambulatory recovery. Diabetes mellitus was an important risk factor for prolonged wound healing, local wound complications and major amputation.en_US
dc.identifier.otherdoi: http://dx.doi.org/10.4314/gmj.v55i1.10
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37354
dc.language.isoen_USen_US
dc.publisherGhana Med Jen_US
dc.subjectPeripheral arterial diseaseen_US
dc.subjectcritical limb ischemiaen_US
dc.subjectpost-operative outcomesen_US
dc.titlePredictors of post-operative outcomes in patients with peripheral arterial disease and critical limb ischaemia: a systematic review and meta-analysisen_US
dc.typeArticleen_US

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