Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of solanum torvum swartz (solanaceae)

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dc.contributor.authorKoffuor, G.A.
dc.contributor.authorKoffuor, G.A.
dc.contributor.authorAmoateng, P.
dc.contributor.authorAndey, T.A.
dc.date.accessioned2013-06-17T13:30:04Z
dc.date.accessioned2017-10-16T11:44:11Z
dc.date.available2013-06-17T13:30:04Z
dc.date.available2017-10-16T11:44:11Z
dc.date.issued2011
dc.description.abstractAim The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity. Materials and Methods Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract. Results The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days. Conclusion: Solanum torvum extract showed a concentration-dependent immunostimulant and erythropoietic activity.en_US
dc.identifier.citationKoffuor, G. A., Amoateng, P., & Andey, T. A. (2011). Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of solanum torvum swartz (solanaceae). Pharmacognosy Research, 3(2), 130-134.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/3306
dc.language.isoenen_US
dc.publisherPharmacognosy Researchen_US
dc.subjectDelayed type hypersensitivity responseen_US
dc.subjectHemagglutinating antibody titeren_US
dc.subjectPhenylhydrazineen_US
dc.subjectSheep red blood cellsen_US
dc.subjectSolanum torvumen_US
dc.titleImmunomodulatory and erythropoietic effects of aqueous extract of the fruits of solanum torvum swartz (solanaceae)en_US
dc.typeArticleen_US

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