Hepatitis B virus genotypes among chronic hepatitis B patients reporting at Korle-Bu teaching hospital, Accra, Ghana

Simple item page
dc.contributor.authorDongdem, A.Z.
dc.contributor.authorDzodzomenyo, M.
dc.contributor.authorAsmah, R.H.
dc.contributor.authorNyarko, K.M.
dc.contributor.authorNortey, P.
dc.contributor.authorAgyei, A.
dc.contributor.authorAdjei, D.N.
dc.contributor.authorKenu, E.
dc.contributor.authorAdjei, A.A.
dc.date.accessioned2019-04-16T09:49:49Z
dc.date.available2019-04-16T09:49:49Z
dc.date.issued2016
dc.description.abstractINTRODUCTION: Knowledge of hepatitis B virus (HBV) genotype is an important predictive variable which might have an impact in management and treatment of patients with chronic hepatitis B infection. In Ghana very little information is available on hepatitis B genotypes. This study was conducted to determine the distribution of HBV genotypes circulating among chronic hepatitis B patients reporting at the Korle-Bu Teaching Hospital (KBTH), Accra, Ghana.METHODS: Blood samples (10 ml) were collected from 250 consenting patients. DNA was extracted and amplified using polymerase chain reaction technique. Restriction fragment length polymorphism (RFLP) was used for the detection of genotypes.RESULTS: Out of the 250 chronic hepatitis B patients who were HBsAg positive, 91 (36.4%) were males aged 29.8 ± 9.1 and 159 (63.6%) females aged 33± 12.1 years. HBV DNA was detected in 111 (44.4%) but only 58 (52%) of these were typeable. These were classified as genotype A, 8 (7.2%); genotype D, 3 (2.7%) and genotype E, 47 (42.3%). Our results did not show any association between the infecting genotype and age (X2= 0.923; p-value=0.623) or gender (X2= 0.283, p= 0.579).CONCLUSION: Consistent with similar studies worldwide, the results suggest that genotypes A, D and E were the genotypes circulating among chronic hepatitis B patients who reported to the Korle-Bu Teaching Hospital with genotype E being the most predominant and therefore constitutes an important public health concern. We recommend further epidemiological studies to understand the implication of genotype E in terms of disease progression and treatment.en_US
dc.identifier.citationDongdem AZ, Dzodzomenyo M, Asmah RH, et al. Hepatitis B virus genotypes among chronic hepatitis B patients reporting at Korle-Bu teaching hospital, Accra, Ghana. Pan Afr Med J. 2016;25(Suppl 1):5. Published 2016 Oct 1. doi:10.11604/pamj.supp.2016.25.1.6170en_US
dc.identifier.issn19378688
dc.identifier.othervol.25(Suppl 1): 5
dc.identifier.otherdoi.10.11604/pamj.supp.2016.25.1.6170
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29289
dc.language.isoenen_US
dc.publisherSAGE Publications Ltden_US
dc.subjectchronic hepatitis B carriersen_US
dc.subjecthepatitis B genotypeen_US
dc.subjectHepatitis B Virusen_US
dc.titleHepatitis B virus genotypes among chronic hepatitis B patients reporting at Korle-Bu teaching hospital, Accra, Ghanaen_US
dc.typeArticleen_US

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Department of Biological, Environmental and Occupational Health