Reversible suppression of bone marrow response to erythropoietin in plasmodium falciparum malaria.

dc.contributor.authorKurtzhals, J.A.L.
dc.contributor.authorRodrigues, O.
dc.contributor.authorAddae, M.
dc.contributor.authorCommey, J.O.O.
dc.contributor.authorNkrumah, F.K.
dc.contributor.authorHviid, L.
dc.date.accessioned2013-06-18T13:34:44Z
dc.date.accessioned2017-10-16T13:07:20Z
dc.date.available2013-06-18T13:34:44Z
dc.date.available2017-10-16T13:07:20Z
dc.date.issued1997
dc.description.abstractTo study the importance of bone marrow inhibition in the pathogenesis of malarial anaemia, haematological and parasitological parameters were followed in patients with acute malaria. Three patient categories were studied, severe malarial anaemia (SA), cerebral malaria (CM) and uncomplicated malaria (UM). Red cell distribution width (RDW) was used as a surrogate marker of release of young erythrocytes and reticulocytes. Initially RDW was low in all patients in spite of markedly increased concentrations of erythropoietin (EPO). 3 d after institution of treatment and coinciding with parasite clearance RDW increased dramatically, reaching the highest levels 1–2 weeks later. Although severe anaemia was corrected by blood transfusion during the first 3 d of treatment, the peak RDW correlated significantly with the initial EPO levels. This suggests that Plasmodium falciparum infection causes a rapidly reversible suppression of the bone marrow response to EPO. Furthermore, the inhibition of bone marrow response was a general finding irrespective of initial haemoglobin levels suggesting that the severity of anaemia depends upon the degree of peripheral erythrocyte destruction in patients with suppressed bone marrow response to EPO.en_US
dc.identifier.citation58. Kurtzhals, J. A. L., Rodrigues, O., Addae, M., Commey, J. O. O., Nkrumah, F. K., & Hviid, L. (1997). Reversible suppression of bone marrow response to erythropoietin in plasmodium falciparum malaria. British Journal of Haematology, 97(1), 169-174.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/3518
dc.language.isoenen_US
dc.publisherBritish Journal of Haematologyen_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectErythropoietinen_US
dc.subjectErythropoiesisen_US
dc.subjectAnaemiaen_US
dc.titleReversible suppression of bone marrow response to erythropoietin in plasmodium falciparum malaria.en_US
dc.typeArticleen_US

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